Home » Products » Midodrine

Product Information

Brand name(s):  

  • Orvaten  

  • ProAmatine

  •  Amatine 

Midodrine works by constricting (narrowing) the blood vessels and increasing blood pressure.

This medicine is used to treat low blood pressure (hypotension) caused by certain conditions or situations such as kidney dialysis. It is also used in children who develop low blood pressure because of infections.

Midodrine may also be used for purposes not listed in this medication guide.

What are the available dosage forms and strengths?


  • 2.5mg

  • 5mg

  • 10mg

How should you take Midodrine (ProAmatine, Orvaten)? 

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use exactly as directed by your healthcare provider.

Midodrine is usually taken 3 times per day, with doses spaced at least 3 hours apart. Do not take your last dose after an evening meal or within four hours before going to bed.

You may take midodrine with or without food.

Take this medicine during your normal waking hours, when you are most likely to be upright and not lying down or napping. Ask your doctor about how to take this medicine if you normally lie down during the day.

Midodrine can increase your blood pressure even while you are lying down or sleeping (when blood pressure is usually lowest). Long-term high blood pressure (hypertension) can lead to serious medical problems.

Follow your doctor’s instructions about the best way to position your body while you are laying down or sleeping. You may need to keep your head elevated to help prevent high blood pressure.

Your blood pressure will need to be checked before and during treatment with midodrine. Check your blood pressure while you are lying down, and check it again with your head elevated.

Your kidney and liver function may also need to be checked.

Midodrine is only part of a treatment program that may also include lifestyle changes, wearing support stockings on your legs, and possibly special medical care. Follow your doctor’s instructions very closely.

Do not take a double dose to make up for a forgotten dose. If you forget to take a dose, take it as soon as you remember it and then take the next dose at the right time.

Store at room temperature; away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

Who should not take Midodrine (ProAmatine, Orvaten)?

You should not use midodrine if you are allergic to it, or if you have:

  • certain forms of heart disease (such as angina) or have suffered a heart attack;

  • kidney disease, or if you are unable to urinate;

  • pheochromocytoma (tumor of the adrenal gland);

  • poor vision as a result of diabetes or have increased pressure in the eye (glaucoma);

  • an enlarged prostate;

  • overactive thyroid; or

  • high blood pressure even while lying down.

What to avoid while taking Midodrine (ProAmatine, Orvaten)?

Avoid taking a dose less than 4 hours before your normal bedtime.

If you are using midodrine hydrochloride, it’s recommended that you get up slowly from sitting or lying down to help reduce dizziness. In addition, limit your use of alcoholic beverages.

Midodrine hydrochloride may make you dizzy, drowsy, or cause blurred vision, so do not drive, use machinery or engage in activities that require you to be alert or have clear vision until you know if you can do so safely.

Ask a doctor or pharmacist before using any over-the-counter diet pills, or cough/cold medicine that contains phenylephrine or pseudoephedrine. These medicines may raise your blood pressure.

What should I tell my healthcare provider before using Midodrine (ProAmatine, Orvaten)?

To make sure midodrine is safe for you, tell your doctor if you:

  • have diabetes;

  • have glaucoma or a history of vision problems;

  • have liver disease;

  • are taking the steroid medication fludrocortisone (Florinef)

  • are using any drugs to treat high blood pressure or

  • have a history of kidney disease.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether midodrine passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

What are the possible side effects of Midodrine (ProAmatine, Orvaten)? 

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking midodrine and call your doctor at once if you have:

  • severely slowed heart rate–weak pulse, severe dizziness or light-headed feeling, vision problems; or

  • dangerously high blood pressure–severe headache, pounding sensation in your ears (“hearing” your heartbeats), blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure.

Common side effects may include:

  • chills, goosebumps;

  • numbness, tingling, or itching (especially in your scalp);

  • headache, dizziness, tired feeling;

  • nausea; or

  • increased urination, painful or difficult urination, or sudden urge to urinate.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

What other drugs interact with Midodrine (ProAmatine, Orvaten)?

Taking midodrine with other drugs that constrict blood vessels can further increase your blood pressure. Tell your doctor about all your current medicines and any you start or stop using, especially:

  • digoxin, digitalis, droxidopa, fludrocortisone

  • an antidepressant;

  • asthma medicine;

  • heart or blood pressure medicine;

  • migraine headache medicine;

  • thyroid medicine such as levothyroid or synthroid;

  • drugs to treat high blood pressure or a prostate disorder–prazosin, terazosin, or doxazosin; or

  • an MAO inhibitor–isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine.

In addition, pay close attention to the labels on cough and cold products, diet aids, and non-steroidal anti-inflammatory drugs (NSAIDS) such as ibuprofen and naproxen since they might contain ingredients that could raise your blood pressure.

This list is not complete. Other drugs may affect this medication, including prescription and over-the-counter medicines, vitamins, and herbal products.

What happens if I overdose?

Seek emergency medical attention

Where can I get more information about Midodrine (ProAmatine, Orvaten)?

If you have any questions about buying discount Midodrine (ProAmatine, Orvaten) or any other prescription products online, you can contact us.

Other Information

Description of Midodrine

Uses of Midodrine

How should you take Midodrine

Precautions and contraindications for Midodrine

In case of overdosage

Warnings and Cautions

Drug interactions


Could not find your medication? Call us!

price icon

For many products we offer a lower per unit cost when you purchase larger quantities. If your quantity is larger than what is available on this website, please contact us directly.

equivalent icon

Brand-name and generic products are therapeutically equivalent.

info icon

Whatever source country you choose, your product will take about the same number of days to arrive.

Discreet Packaging

Your order for Midodrine will be shipped in discreet packaging so whether the item is shipped to your home or work no one will know the contents of the shipment until opened.

Delivery Timetable

Average regular delivery time:
10 days from our Canadian online pharmacy.

Delivery times for Midodrine do vary depending on the location of the dispensary. The reason deliveries take time is primarily due to customs procedures that need to be completed prior to allowing our packages to enter the United States. Expedited and tracked delivery services are available from our Canadian online dispensary. Please speak to one of our online pharmacy service representatives if you have any questions about delivery times for your order.

Product Reviews

Your overall rating

The prescription medications you have requested were lawfully prescribed by a qualified and licensed physician. You have attended, have had a physical examination, and have received a prescription from a duly licensed practitioner within the last year, and do not require an additional physical examination. You have not altered your prescription in any way. The duty of care with respect to the prescribing of your medications is and shall remain the responsibility of your physician. You will consult with your physician for any appropriate monitoring and testing. You will use your medication only as directed by your physician and will remain under the care of your physician while taking your medication. Except as specifically authorized by law (and further clarified herein), you are not purchasing medications for anyone else, and you will be the only person using the medications prescribed for you. In the event that you are unable to personally place your order with CheapoMeds due to age or infirmity, you can authorize someone else to place your order and assist you in acquiring your medications, so long as they have power of attorney over your affairs, and provide a copy of their legal authorization to act on your behalf to CheapoMeds.