Stop taking your statin because of muscle pain? We may have a new solution for you!


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Are you currently taking a statin and have been experiencing muscle pain? Have you stopped taking your statin entirely because of the way it made you feel? You’re not alone!

Over 71 million Americans live with high cholesterol and have likely been recommended by their healthcare provider to start taking a statin medication.

Managing Cholesterol with Statin Medication

High levels of bad cholesterol, known as LDL-C, contribute to the development of heart disease. When your cholesterol levels are too high, deposits of fat can build up on the walls of your arteries, and over time, can lead to a higher risk of a heart attack.

Statin medications are the first line of defense healthcare providers use to help manage high cholesterol levels in their patients. Statins have been around for over 30 years and are the most widely prescribed medication in the U.S.

Not all statins are the same.

Statin Side Effects and Muscle Pain

While statins are generally well tolerated, they are not without their risk of side effects. It is important to continue taking your statin to lower your levels of bad cholesterol and lower your risk of developing cardiovascular disease or having a heart attack.

The most commonly reported side effect from patients taking statin therapy is muscle pain, or myalgia. As a rule of thumb, the higher the dose of statin, the more likely muscle pain is to occur.

Zypitamag may be an option for you!

Zypitamag (pitavastatin) tablets are a new statin on the market. Pitavastatin 4 mg tablets can reduce bad cholesterol by up to 44% and increase good cholesterol by up to 7%.

At the highest dose (4 mg), only 3.1% of patients experienced myalgia, with less than 4% discontinuing the product.

If you are taking a statin and experiencing muscle pain, ask your healthcare provider if Zypitamag (pitavastatin) tablets might be an option for you.

Zypitamag is available in 2 mg and 4 mg formats available at around $1 a day! Click to learn more about how Zypitamag is different from other statins.

This article contains information about an FDA-approved product, Zypitamag (pitavastatin) tablets. This medication is available by prescription only. Talk to your doctor to see if Zypitamag is right for you. Please refer to the Zypitamag (pitavastatin) tablets Important Safety Information below and Prescribing Information for more information.


Who should NOT take ZYPITAMAG?

ZYPITAMAG is not right for everyone. Do not take ZYPITAMAG if:

  • You have a known allergy to ZYPITAMAG or any of its ingredients.
  • You have active liver problems, including some abnormal liver test results.
  • You are nursing, pregnant or may become pregnant, as it may harm the baby.
  • You are currently taking cyclosporine or gemfibrozil.

What is the most important information I should know and talk to my doctor about?

  • Call your healthcare provider or get help right away if you experience any symptoms of an allergic reaction, such as rash, itching, or hives.
  • Muscle problems may be an early sign of rare, serious conditions. Tell your doctor right away if you have any unexplained muscle pain, weakness, or tenderness, particularly if accompanied by malaise or fever, or if these muscle signs or symptoms persist after discontinuing ZYPITAMAG.
  • Serious liver problems have been reported rarely in patients taking statins, including pitavastatin. Your doctor should do liver tests before you start, and if you have symptoms of liver problems while you are taking ZYPITAMAG. Tell your healthcare provider right away if you feel more tired than usual, have a loss of appetite, upper belly pain, dark-colored urine, or yellowing of the skin or eyes.
  • Tell your doctor about all your medical conditions and medications you take including nonprescription medicines, vitamins, or herbal supplements.
  • Increases in blood sugar levels have been reported with statins, including pitavastatin.
  • Tell your doctor about your alcohol use.
  • Tell your healthcare provider of a known or suspected pregnancy.

What are the most common side effects of ZYPITAMAG?

The most common side effects of ZYPITAMAG in clinical studies were:

  • Back pain
  • Constipation
  • Diarrhea
  • Muscle pain
  • Pain in the legs or arms

This is not a complete list of side effects. Talk to your healthcare provider for more information.

You are encouraged to report negative side effects of all drugs to the FDA. Visit or call 1-800-FDA-1088.

How should I store and take ZYPITAMAG?

  • Store ZYPITAMAG tablets at room temperature, in a dry place, and out of the reach of children.
  • Take ZYPITAMAG orally once daily with or without food at the same time each day.
  • Swallow the tablet whole. Do not split, crush, dissolve, or chew.
  • The maximum recommended dosage is ZYPITAMAG 4 mg once daily.
  • If you take too much ZYPITAMAG or you or someone else takes an overdose, call your doctor and/or local Poison Control Center.

Other important information I should know about ZYPITAMAG.

  • ZYPITAMAG has not been studied to evaluate its effect on reducing heart-related disease or death.
  • ZYPITAMAG is available by prescription only.

For additional information, please see the full Prescribing Information.

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